The study finds good mental health in adolescents born after assisted reproduction

Solna [], 31 December (): A new study by Karolinska Institutet found a slightly higher risk of obsessive-compulsive disorder for those born after ART, but this was explained by the parents’ background factors.

The research has been published in the ‘JAMA Journal’.

“These results are generally reassuring in terms of the psychiatric of adolescents born with ART, a group that we can now follow for the first into early adulthood,” said the study’s corresponding author Chen Wang, a doctoral student at the Department of Medical Epidemiology. and biostatistics at Karolinska Institutet.

Since 1978, more than 9 million children have been born using assisted reproduction technology. In vitro fertilization (IVF) has revolutionized the treatment of infertility to such an extent that Robert G. Edwards was awarded the 2010 in Physiology or for its development. Previous studies, however, have linked the use of ART to certain unwanted birth outcomes such as an increased risk of birth defects, premature birth and low birth weight.

Knowledge about the long-term health of children born with ART is still limited. Now, researchers at Karolinska Institutet have conducted the first major study on in young adults born in Sweden after ART.

Using individually linked population-based data, the researchers were able to follow more than 1.2 million people born in Sweden between 1994 and 2006, including 31,565 participants who were fertilized with ART. The participants were between 12 and 25 years old when the study ended. The researchers also had access to registry-based information on clinical diagnoses of mood disorders such as depression, , obsessive-compulsive disorder (OCD) or suicidal behavior.

In addition to the potential effects of the intervention, certain characteristics and characteristics that may be more common in couples undergoing ART may also play a role in their children’s long-term health. In the study, the researchers were therefore particularly careful to distinguish the role of treatment from the influence of a wide range of parents’ background factors, such as infertility, age of mother and father, education and mental health.

“Finally, we did not find that the use of ART had any negative impact on children’s psychiatric health as they went through adolescence. Individuals pregnant with ART had a slightly increased risk of OCD compared to the population but this was explained by differences in parental background. , as this excess risk no longer existed after adjustment for different parental characteristics “, says former author Sara Oberg, associate professor at the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet. (ANI)


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